Artículos

Treatment of acute otitis media in children under 2 years of age

Hoberman A, Paradise JL, Rockette HE, Shaikh N, Wald ER, Kearney DH, Colborn DK, Kurs-Lasky M, Bhatnagar S, Haralam MA, Zoffel LM, Jenkins C, Pope MA, Balentine TL, Barbadora KA; New England Journal of Medicine (NEJM) 364 (2), 105-15 (Jan 2011)


BACKGROUND Recommendations vary regarding immediate antimicrobial treatment versus watchful waiting for children younger than 2 years of age with acute otitis media.

METHODS
We randomly assigned 291 children 6 to 23 months of age, with acute otitis media diagnosed with the use of stringent criteria, to receive amoxicillin-clavulanate or placebo for 10 days. We measured symptomatic response and rates of clinical failure. 

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Induction chemotherapy with cisplatin and fluorouracil alone or in combination with docetaxel in locally advanced squamous-cell cancer of the head and neck: long-term results of the TAX 324 randomised phase 3 trial

 Lorch JH, Goloubeva O, Haddad RI, Cullen K, Sarlis N, Tishler R, Tan M, Fasciano J, Sammartino DE, Posner MR, for the TAX 324 Study Group; Lancet Oncology (Jan 2011)


BACKGROUND:
At a minimum follow-up of 2 years, the TAX 324 study showed a significant survival benefit of induction chemotherapy with docetaxel, cisplatin, and fluorouracil (TPF) versus cisplatin and fluorouracil (PF) in locally advanced head and neck cancer. We report the long-term results at 5 years' minimum follow-up. 

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The use of adalimumab for cricoarytenoid arthritis in ankylosing spondylitis-an effective therapy

Desuter G, Duprez T, Huart C, Gardiner Q, Verbruggen G; The Laryngoscope (Jan 2011)

This report describes cartilaginous regeneration in a cricoarytenoid joint affected by spondyloarthropathy using tumor necrosis factor-alpha (TNF-α) blockade, monitored by magnetic resonance (MR) and computed tomography (CT) imaging. This case is interesting for several reasons. 

 

Leer más: The use of adalimumab for cricoarytenoid arthritis in ankylosing spondylitis-an effective therapy

Vocal cord dysfunction: what do we know?

Kenn K, Balkissoon R; European Respiratory Journal 37 (1), 194-200 (Jan 2011)

Vocal cord dysfunction (VCD) is a disorder caused by episodic unintentional paradoxical adduction of the vocal cords, which may induce acute severe dyspnoea attacks not responsive to conventional asthma therapy. The aetiology of VCD is complex and often multifactorial. 

Leer más: Vocal cord dysfunction: what do we know?