Human papillomavirus in head and neck cancers: biology, prognosis, hope of treatment, and vaccines
Psyrri A, Boutati E, Karageorgopoulou S; Anti-Cancer Drugs (Mar 2011)
Human papillomaviruses (HPVs), especially type 16, are implicated in the development of a subset of head and neck squamous cell cancers (HNSCCs).
Leer más: Human papillomavirus in head and neck cancers: biology, prognosis, hope of treatment, and vaccines
Sudden Sensorineural Hearing Loss: Subclinical Viral and Toxoplasmosis Infections as Aetiology and How They Alter the Clinical Course
Kikidis D, Nikolopoulos TP, Kampessis G, Stamatiou G, Chrysovergis A; ORL: Journal of Oto-Rhino-Laryngology and Its Related Specialties 73 (2), 110-115 (Mar 2011)
Aim: To explore in a prospective study the evidence of certain viral and toxoplasmosis infections in sudden sensorineural hearing loss (SSHL).
Leer más: Sudden Sensorineural Hearing Loss: Subclinical Viral and Toxoplasmosis Infections as Aetiology and...
Computed tomography and magnetic resonance imaging findings before and after treatment of patients with malignant external otitis
Al-Noury K, Lotfy A; European Archives of Oto-Rhino-Laryngology (Mar 2011)
The aim of our prospective study is to illustrate the role of computed tomography (CT) and magnetic resonance imaging (MRI) in the diagnosis and delineation of the extent of disease in malignant external otitis (MEO) at presentation and following successful treatment.
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The incidence of Epstein-Barr virus in nasopharyngeal carcinoma of Jordanian patients
Matalka I, Al Hamad M, Al-Hussaini M, Alzoubi FQ; European Archives of Oto-Rhino-Laryngology (Mar 2011)
Aim of this study was to investigate the incidence of Epstein-Barr virus (EBV) in patients diagnosed with undifferentiated nasopharyngeal carcinoma (UNPC) from the Northern Province of Jordan. All cases diagnosed with UNPC at King Abdullah University Hospital, Irbid, Jordan, between the years 1991 and 2009 inclusive were examined.
Leer más: The incidence of Epstein-Barr virus in nasopharyngeal carcinoma of Jordanian patients
Endoscopic approach to the orbital apex and periorbital skull base
Murchison AP, Rosen MR, Evans JJ, Bilyk JR; The Laryngoscope 121 (3), 463-7 (Mar 2011)
OBJECTIVES/HYPOTHESIS To review cases of endoscopic orbital apex and periorbital skull base surgery and stratify the pathology and lesion location. Variations in surgical technique and the outcomes are reviewed. We report the results of all cases of endoscopic orbital apex surgery over a 40-month period.
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Treatment of sudden sensorineural hearing loss with transtympanic injection of steroids as single therapy: a randomized clinical study
Dispenza F, Amodio E, De Stefano A, Gallina S, Marchese D, Mathur N, Riggio F; European Archives of Oto-Rhino-Laryngology (Feb 2011)
The aim of this study was to verify the efficacy and the safety of transtympanic dexamethasone to treat sudden sensorineural hearing loss as first and single drug method. Considering ethical implication of performing a mininvasive procedure on middle ear, we matched such proposed treatment with systemic prednisone administration that represents the widest adopted protocol. Randomized prospective study was conducted. The inclusion criterion was a sudden sensorineural hearing loss of at least 30 dB across three contiguous frequencies over a period of 24 h. Group A received transtympanic steroid injections; Group B received oral administration of steroids. 25 patients were treated with transtympanic therapy whereas 21 underwent systemic treatment. The mean of initial PTA was 59 dB for the whole series: 65 dB for group A and 51 dB for group B. The recovery better than 10 dB was obtained in 80% of patients of group A and in 17 81% of patients of group B, with a total of 80.5%. The mean relative gain in PTA was 41.16% in the group A and 44.7% in the group B. In the frequencies tested (0.5, 1, 2, and 4 kHz) PTA improvements after transtympanic treatment were higher than after systemic treatment, but these differences were not statistically significant (P = 0.61). Both transtympanic and systemic treatment had similar clinical recovery times. This prospective randomized clinical study showed good result in terms of hearing recovery, better than the expected results of the simple observation without treatment. We can consider transtympanic administration as a first line treatment, because of the statistical analysis confirmed similar results with systemic therapy, reducing possible side effects of systemic drug administration. The delay of treatment does not influence the outcome, allowing treating patients within 10 days of onset.
Angiotensin II receptor blocker-induced angioedema in the oral floor and epiglottis
Shino M, Takahashi K, Murata T, Iida H, Yasuoka Y, Furuya N; American Journal of Otolaryngology (Feb 2011)
We report the rare case of angioedema (also known as Quincke edema), which was induced by valsartan, an angiotensin II receptor blocker (ARB). ARBs are a new class of antihypertensive agent that is developed to exclude the adverse effects of angiotensin-converting enzyme inhibitors. In theory, ARBs do not contribute to the occurrence of angioedema because they do not increase the serum level of bradykinin, the responsible substance for angioedema. However, some reports of ARB-induced angioedema have recently been published. In this study, we present the forth case and the first Asian case of angioedema due to valsartan, which is one of the ARBs. Otolaryngologist should be wary of the prescribing ARB and discontinue ARBs treatment soon, if angioedema is recognized.